Professor Skene is a Professor of Law in the Faculty of Law and an Adjunct Professor in the Faculty of Medicine Dentistry and Health Sciences at the University of Melbourne. She is a member of the NHMRC Legislation Review Committee on Human Cloning and Embryo Research (the Heerey Committee); the Australian Health Ethics Committee, one of the principal Committees of the National Health and Medical Research Council; and the Australian Workforce Advisory Council. She has served on numerous federal and state advisory committees, especially in relation to genetics and the law. In 2005, she was Deputy Chair of the Lockhart Committee on Human Cloning and Embryo Research and became principal spokesperson for the Committee after the sudden death of the Chair, the late Justice Lockhart AO, in January 2006.
She is the author of two books on medical law (including the widely used text, Law and Medical Practice, 1st ed Butterworths, Sydney, 1998; 2nd ed LexisNexis, Sydney, 2004; 3rd ed, LexisNexis, Sydney, 2008); and numerous chapters in books and articles in Australian and overseas legal, medical and scientific journals. In 2003, she was awarded a Centenary Medal for 'Service to Australian Society through the Exploration of Legal and Ethical Issues of Health Care'.